![]() ![]() NHANES is a nationally representative survey of the noninstitutionalized adult population of the United States, conducted biennially by the Centers for Disease Control and Prevention. Hence, we undertook a large population study with data from the National Health and Nutrition Examination Survey (NHANES) to determine the relationship between values of MPV and CRP and to explore the potential role of MPV in the assessment of the severity of inflammation. Alternatively, MPV depends on multiple factors and thus lacks a simple correlation with CRP. We hypothesized that a positive correlation between MPV and CRP might indicate that MPV could be used as an inflammatory marker, and thus a simple complete blood count (including MPV) could be useful in the assessment of the degree of inflammation in patients. 7–9 Information on possible dynamic aspects of this relationship across physiological and pathological conditions is not available. 6 Clinical studies investigating the potential correlation between CRP and MPV values in patients with inflammatory states have produced variable results. 5 Inflammatory cytokines and chemokines increase the formation and activation of platelets and lead to the dissociation of proinflammatory monomeric CRP from its native pentameric form. 4 C-reactive protein (CRP), an acute-phase reactant produced by the liver, is an established marker of inflammation. 2, 3 An increase in MPV has been associated with increased mortality in sepsis, which is a severe acute inflammatory state. 1 Mean platelet volume (MPV) is a measure of platelet size and activation and has been implicated in various diseases in recent studies. They potentiate inflammation and immunity against infective agents through active phagocytosis, degranulation, and recruitment of leukocytes to sites of infection. Platelets have an important role as mediators of inflammation and hemostasis. Our study revealed a significant inverse correlation between MPV and CRP in NHANES participants. In adjusted regression models using CRP categories, participants with high CRP (>3 mg/dL) had significantly lower MPV compared with the low CRP group (b = −0.20 standard error 0.09 95% confidence interval −0.38 to −0.01 P = 0.035). In adjusted regression models with CRP as a continuous measure, individuals with high CRP had significantly lower MPV (b = −0.04 standard error 0.01 95% confidence interval −0.06 to −0.01 P = 0.002). Overall mean CRP in the population was 0.4 mg/dL (standard deviation 0.78). In 16,329 participants, mean MPV was 7.9 fL (standard deviation 0.87). Statistical analyses were performed with Stata MP 15.1. ![]() Multivariate ordinary least squares regression analysis was used to predict the association. CRP was analyzed both as a continuous variable and as a categorical variable (low, intermediate, or high). We undertook a population study with the National Health and Nutrition Examination Survey (NHANES) data (2005-2010) to investigate the relationship between CRP and MPV. Studies on the correlation between MPV and CRP have produced ambiguous results. Mean platelet volume (MPV) is a measure of platelet activation, and C-reactive protein (CRP) is an established marker of inflammation. ![]()
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